Sole acquired trisomy 21 in a case of CD7 and CD10 positive acute myeloid leukemia.

132 CMYK leukemoid reaction in bladder cancer. All six cases were associated with aggressive tumor cell growth and unfavorable clinical outcome. Only in one of the previously reported cases were fever and leukemoid reaction the presenting features of bladder cancer without any obvious metastases.[2] Two patients had rapid local recurrence six weeks after surgery.[3] Distant liver metastases at initial presentation were present in another two patients.[1,4] In one patient the tumor had already invaded the pelvic wall at the time of diagnosis.[5] Leukemoid reactions probably are caused by mechanical stimuli on bone marrow, resulting from bone metastases, or they may be caused by humoral stimuli resulting from neosynthesized blastic factors or factors released from the foci of tumor necrosis. Paraneoplastic leukocytosis associated with bladder carcinoma has been shown to result from autonomous production of G-CSF by the tumor.[3,4] Fever is an integral component of leukemoid reaction resulting from either release of endogenous pyrogens or due to necrotic-inflammatory phenomena of the tumor.